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目的:探讨联合检测患者血清中P选择素(P-sel)、层黏连蛋白(LN)、α-L岩藻糖苷酶(AFU)及谷酰转肽酶(γ-GT)对提高原发性肝癌的检出率的意义。方法:用ELISA法检测四组人员的P-sel、LN的含量,用全自动生化分析仪检测AFU、γ-GT的含量。结果:肝癌患者血清中四项指标含量及阳性率明显高于正常对照组(P<0.01)、肝硬化组(P<0.05)或乙肝患者组(P<0.01),联合检测四项指标均为阳性的人群,肝癌患者也明显高于肝硬化患者。结论:联合检测四项指标可提高原发性肝癌的检出率,具有较大的临床意义。
Objective: To investigate the effects of P-sel, LN, AFU and γ-GT on the serum levels of primary The significance of detection rate of HCC. Methods: The contents of P-sel and LN in four groups were detected by ELISA. The contents of AFU and γ-GT were detected by automatic biochemical analyzer. Results: The content and positive rate of four indexes in serum of patients with hepatocellular carcinoma were significantly higher than those in normal control group (P <0.01), cirrhosis group (P <0.05) or hepatitis B patients group (P <0.01) Positive people, liver cancer patients were significantly higher than cirrhosis patients. Conclusion: The combined detection of four indicators can improve the detection rate of primary liver cancer, which has great clinical significance.