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目的探讨基因芯片在诊断β地中海贫血中的价值。方法对经筛查初诊的32例β地贫进行基因芯片检测并与斑点杂交法进行比较分析。结果32例β地贫中,基因芯片技术检出32例,斑点杂交法检出30例,两者差别无统计意义(P>0.05)。结论基因芯片技术与斑点杂交法在β地贫的诊断上可以互相代替;基因芯片技术具有快速、高效、自动化等特点且简便、经济、省时省力,较斑点杂交法优越,宜提倡推广应用。
Objective To investigate the value of gene chip in the diagnosis of β-thalassemia. Methods Thirty-two cases of β-thalassemia newly diagnosed by screening were detected by gene chip and compared with the dot blot hybridization. Results Among 32 cases of β-thalassemia, 32 cases were detected by gene chip technology and 30 cases were detected by dot blot hybridization. There was no significant difference between them (P> 0.05). Conclusion Gene chip technology and dot blot hybridization can replace each other in the diagnosis of β-thalassemia. Gene chip technology is fast, efficient and automatic. It is simple, economical, time-saving and labor-saving.