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目的:观察和探讨不同煎煮方法对血府逐瘀汤浸出物和主成分的影响,针对固方汤剂多科室普及应用,扩大医院制剂发展提供新的思路和方法。方法:入选于本院就诊的冠心病心绞痛患者70例,下肢静脉血栓40例,慢性肾功能不全30例,将入选患者随机分为观察组和对照组,采用双盲原则进行试验研究,治疗组给予固方血府逐瘀汤治疗,对照组给予阳性对照药物干预,对两组患者治疗前后疗效性进行对比研究。结果:传统煎煮对比煎药机煎煮总浸出物含量明显较高,差异显著,P<0.05;煎药机煎煮羟基红花黄色素A、芍药苷和柚皮苷含量均较传统煎煮有所提高,差异显著,P<0.05;在多科室应用血府逐瘀汤进行异病同治原则下的辨证治疗,研究结果显示,冠心病心绞痛总有效率高达92.1%,下肢静脉血栓总有效率高达93.2%,慢性肾功能不全总有效率高达89.7%,组间差异均具有显著性,P<0.05。结论:煎药机煎煮法浸出物含量较高,具有一定优势,将血府逐瘀汤进行多科室普及应用具有积极意义。
Objective: To observe and discuss the effects of different decoction methods on the extract and main components of Xuefuzhuyu decoction, provide new ideas and methods for the popularization and application of decoction of Gufang decoction and expand the development of hospital preparations. Methods: Seventy patients with angina pectoris, 40 patients with venous thrombosis of lower extremity and 30 patients with chronic renal insufficiency were enrolled in this study. The patients were randomly divided into observation group and control group. The treatment group Given Gufudzhuyu Decoction treatment, the control group were given positive control drug intervention, the efficacy of two groups of patients before and after treatment were compared. Results: Compared with the traditional decoction machine, the content of total extractives in decoction was significantly higher, P <0.05; the content of hydroxysafflor yellow A, paeoniflorin and naringin in decocting machines were significantly lower than those in traditional decoction The difference was significant, P <0.05; the application of Xuefu Zhuyu Decoction in multiple departments of different diseases under the principle of the same syndrome differentiation treatment, the results show that the total effective rate of coronary heart disease angina up to 92.1%, the total effective rate of venous thrombosis of lower extremity Up to 93.2%. The total effective rate of chronic renal insufficiency was as high as 89.7%. There was significant difference between the two groups (P <0.05). Conclusion: The decoction of decoction machine has higher content of extract, which has some advantages. It is of great significance to use Xuefuzhuyu Decoction in multi-departmental popularization.