腎素——血管紧张素及其拮抗剂的若干临床应用

• 作 者: 邵安华
• 机 构: 上海市第一人民医院内科,
• 出 处: 心血管病译文
• 发表日期: 1982年03期
• 关键词: 血管紧张素 肾素 拮抗剂 醛固酮分泌 血管紧张素Ⅱ 血压 提取物 低肾素型高血压 原发性高血压 高血压者

早在1898年Tigesteat和Bergnlan将兔的肾脏提取物注于另一麻醉的免,可使血压增高,以后曾称该物为“肾素”。嗣后经研究,此种“肾素”系由多种不同的肽类物质组成,且有酶参与作用,而称作“肾素——血管紧张素系统”(简称RAS)。因血管紧张素Ⅱ可使醛固酮分泌,故也有人称以

As early as 1898, Tigesteat and Bergnlan injected the rabbit’s kidney extract into another anesthesia-free device, which increased blood pressure and was later described as “renin.” Later studied, this “renin” is composed of a variety of different peptide substances, and enzymes involved, and called “renin - angiotensin system” (referred to as RAS). Because of angiotensin II aldosterone secretion, it was also called