甲状腺功能正常的地甲肿病人TSH分泌的生理节律和波动情况

• 作 者: P.Weber 李生团
• 出 处: 地方病译丛
• 发表日期: 1992年02期
• 关键词: 甲状腺细胞 地方性甲状腺肿 甲状腺功能正常 缺碘地区 波动情况 生理节律 刺激作用 病理生理作用 抑制作用 非毒性

TSH 在地方性甲状腺肿发生中的病理生理作用仍是有争议的,还无明确的证据表明发病时这种激素的分泌有何改变。有人报道,在体外,TSH 对甲状腺细胞的生长有刺激作用,而同时却另有报道指出 TSH 对甲状腺细胞的增殖无作用,甚至能产生抑制作用。流调表明,只有在严重缺碘地区,地甲肿病人的基础 TSH 水平才有升高;而轻微或中等缺碘地区,如西德,地甲肿病人的基础 TSH 水平

The pathophysiological role of TSH in endemic goiter remains controversial and there is no clear evidence of any change in the secretion of this hormone at onset. It was reported in vitro, TSH stimulate the growth of thyroid cells, but at the same time, there are reports that TSH has no effect on the proliferation of thyroid cells, and even inhibitory effect. Fluctuations show that only in areas with severe iodine deficiency, patients with congenital gland swelling TSH levels have increased; and mild or moderate iodine deficiency areas, such as West Germany, gland disease in patients with basal TSH levels