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eIF4E作为翻译启动因子复合体eIF4 F的关键部分 ,调节细胞的蛋白质合成的限速步骤。ras基因加强eIF4E的磷酸化 ,c myc基因增加eIF4EmRNA水平 ;eIF4E活性随其本身磷酸化的加强而加强 ,随其结合蛋白的磷酸化加强而减弱。eIF4E是新近发现的原癌基因 ,过量的eIF4E选择性地加强原癌基因等“弱mRNA”的翻译 :可以通过加强蛋白质合成的速度 ,也可以加速mRNA由细胞核向胞浆转移
eIF4E acts as a key part of the translation initiation factor complex eIF4 F, a rate-limiting step that regulates cellular protein synthesis. ras gene enhanced phosphorylation of eIF4E, c myc gene increased eIF4EmRNA level; eIF4E activity with its own phosphorylation strengthened and strengthened, with its binding protein phosphorylation strengthened and weakened. eIF4E is a recently discovered proto-oncogene. Excess eIF4E selectively enhances the translation of “weak mRNAs” such as proto-oncogenes by either increasing the rate of protein synthesis or expediting the transfer of mRNA from nucleus to cytoplasm