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运用柱层析、比色技术测定了大鼠口服及静脉注射低分子肝素后的血浆药物浓度—时间曲线，并以梯形法求算出大鼠口服低分子肝素的绝对生物利用度。结果表明，低分子肝素口服后可快速进入体内，绝对生物利用度为89．9％，为低分子肝素口服制剂的研究提供了重要的依据。
The plasma concentration-time curves of rats after oral and intravenous low molecular weight heparin were determined by column chromatography and colorimetric techniques. The absolute bioavailability of oral LMWH was calculated by trapezoidal method. The results show that low molecular weight heparin can enter the body rapidly after oral administration, with an absolute bioavailability of 89.9%, which provides an important basis for the study of low molecular weight heparin oral preparations.