论文部分内容阅读
Objective: To determine the expression of α1 and β3 integrin subunit on the endometrium of infertile patients with hydrosalpinx and infertile patients with tubal phimosis. Design: Case-control study. Setting: Tertiary medical center. Patient( s): Infertile patients with radiologic or laparoscopic diagnosis of hydrosalpinx (n = 11) or tubal phimosis (n = 12) as the only cause of infertility, and fertile controls (n = 17). Intervention(s): Immunohistochemical analysis of α1 and β3 integrin subunits was performed on endometrial biopsies obtained during the implantation window. Main Outcome Measure(s): Histologic score (HSCORE) on luminal and glandular endometrium of the patients with hydrosalpinx or tubal phimosis and the normal fertile controls. Result(s): The median (±SEM) HSCORE for β3 subunit expression in endometrial glands was 0.39 ±0.23 and 0.42 ±0.18 for tubal phimosis and hydrosalpinx, respectively, and 1.74 ±0.26 for fertile controls. The median HSCORE for β3 subunit expression in luminal epithelium for tubal phimosis, hydrosalpinx, and fertile controls was 0.07 ±0.06, 0.21 ±0.18, and 1.03 ±0.31, respectively. No statistical difference was observed on the expression of α1 integrin subunit expression between the three groups. Conclusion(s): The endometrial expression of β3 integrin subunit is reduced in the presence of tubal phimosis or hydrosalpinx, during the window of implantation.
Objective: To determine the expression of α1 and β3 integrin subunit on the endometrium of infertile patients with hydrosalpinx and infertile patients with tubal phimosis. Design: Case-control study. laparoscopic diagnosis of hydrosalpinx (n = 11) or tubal phimosis (n = 12) as the only cause of infertility and fertile controls (n = 17). Intervention (s): Immunohistochemical analysis of al and beta3 integrin subunits was performed on endometrial The main Outcome Measure (s): Histologic score (HSCORE) on luminal and glandular endometrium of the patients with hydrosalpinx or tubal phimosis and the normal fertile controls. Results (s): The median (± SEM) HSCORE for β3 subunit expression in endometrial glands was 0.39 ± 0.23 and 0.42 ± 0.18 for tubal phimosis and hydrosalpinx, respectively, and 1.74 ± 0.26 for fertile controls. The median HSCORE for β3 subunit e xpression in luminal epithelium for tubal phimosis, hydrosalpinx, and fertile controls was 0.07 ± 0.06, 0.21 ± 0.18, and 1.03 ± 0.31, respectively. No statistical difference was observed on the expression of α1 integrin subunit expression between the three groups. ): The endometrial expression of β3 integrin subunit is reduced in the presence of tubal phimosis or hydrosalpinx, during the window of implantation.