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作者以6周龄轮状病毒抗体阴性balb/ c雌鼠及其后代为研究对象,用结合脂质佐剂的福马林灭活的轮状病毒疫苗给予胃肠道外免疫,观察其免疫原性和预防腹泻的保护效力。 用0 .0 1 %福马林灭活的恒河猴轮状病毒( I- RRV) (灭活前病毒含量为2×1 0 8pfu/剂)单独或与脂质佐剂〔从沙?
In this study, 6-week-old rotavirus negative balb / c female mice and their offspring were enrolled in this study. The immunized mice were immunized with a combination of lipid adjuvant and fumagin-inactivated rotavirus vaccine And prevent the protective effect of diarrhea. Animals were challenged with 0.1% of the wild-type rhesus rotavirus (I-RRV) inactivated before inactivation (2 x 108 pfu / dose) alone or in combination with a lipid adjuvant [