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暴露于急性缺氧环境会发生缺氧应激反应,过强的缺氧应激反应可导致机体各种功能出现衰竭,机体的神经系统、呼吸系统、循环系统等会受到不同程度的损伤,从而引起机体一系列功能、代谢和结构的病理生理学改变,最终导致心、脑等重要脏器由于能量供应不足而死亡。本文采用基因芯片技术,筛选差异表达基因,旨在研究低压缺氧对大鼠脑皮质基因表达谱及其TAC1和MT1A变化的影响。作者选取24只Wistar大鼠,将其随机分为对照组、3 000m缺氧组和7 000m缺氧组,每组8
Hypoxic stress response occurs when exposed to acute hypoxia. Excess hypoxia stress can cause various functions of the body to fail. The nervous system, respiratory system and circulatory system of the body will be damaged to different extents. Cause a series of body functions, metabolism and structural pathophysiology changes, eventually leading to heart, brain and other vital organs due to lack of energy supply and death. In this paper, gene chip technology was used to screen differentially expressed genes in order to study the effect of hypobaric hypoxia on the gene expression profile and the changes of TAC1 and MT1A in rat cerebral cortex. The authors selected 24 Wistar rats, were randomly divided into control group, 3000m hypoxia group and 7 000m hypoxia group, each group 8