论文部分内容阅读
Aim:To test the effects of atenolol and amlodipine,either alone or in combination,on blood pressure,blood pressure variability (BPV),baroreflex sensitivity (BRS),and the prevalence of stroke in stroke-prone spontaneously hypertensive rats(SHR-SP).Methods:In the first set of the study,24 8-month-old,female SHR-SPrats were randomly divided into 3 groups.Blood pressure,heart period,and BRSwere determined before and after the intragastric administration of atenolol (10mg/kg) and amlodipine (1.0 mg/kg),either alone or in combination.In the secondset of the study,40 male and 40 female rats were randomly assigned to 1 of thefollowing 4 groups:control,atenolol (10 mg·kg~(-1)·d~(-1)),amlodipine (1.0 mg·kg~(-1)·d~(-1)),and both (10 male and 10 female in each group).The stroke incident and survivaltime were recorded.Results:Atenolol and amlodipine,either alone or incombination,significantly decreased blood pressure,with the exception of theamlodipine-induced effect on diastolic blood pressure.Meanwhile,only the com-bination treatment significantly decreased the BPV levels for the same period.The q-values calculated by the probability sum analysis were 1.17 and 2.67 forsystolic and diastolic blood pressure,respectively,and were 2.48 and 2.10 forsystolic and diastolic BPV,respectively,following administration.Neither drugexhibited any significant effect on BRS.Atenolol and amlodipine,either alone orin combination,significantly increased the lifespan of SHR-SP,with the best ef-fect elicited by the combination therapy.Conclusion:A significant synergismexists between atenolol and amlodipine in lowering and stabilizing blood pressurein SHR-SP.Combination therapy may be an optimal strategy for the prevention ofstroke in hypertension.
Aim: To test the effects of atenolol and amlodipine, either alone or in combination, on blood pressure, blood pressure variability (BPV), baroreflex sensitivity (BRS), and the prevalence of stroke in stroke-prone spontaneously hypertensive rats ). Methods: In the first set of the study, 24 8-month-old, female SHR-SPrats were randomly divided into 3 groups. Blood pressure, heart period, and BR We determined before and after the intragastric administration of atenolol (10 mg / kg) and amlodipine (1.0 mg / kg), either alone or in combination.In the second set of the study, 40 male and 40 female rats were randomly assigned to 1 of the following 4 groups: control, atenolol (10 mg · kg ~ (1) · d -1), amlodipine (1.0 mg · kg -1 · d -1), and both (10 male and 10 female in each group). The stroke incident and survivaltime were recorded. Results: Atenolol and amlodipine, either alone or incombination, significantly decreased blood pressure, with the exception of the amlodipine-induced effect on diastolic blood pressure .Meanwhile, only the com-bination treatment significantly decreased the BPV levels for the same period. The q-values were calculated by the probability sum analysis were 1.17 and 2.67 forsystolic and diastolic blood pressure, respectively, and were 2.48 and 2.10 forsystolic and diastolic BPV , respectively, the following administration. Neither drugexhibited any significant effect on BRS. Atenolol and amlodipine, either alone or in combination, significantly increased the lifespan of SHR-SP, with the best ef-fect elicited by the combination therapy. Conlusion: A significant synergismexists between atenolol and amlodipine in lowering and stabilizing blood pressure in SHR-SP. Combining therapy may be an optimal strategy for the prevention of stroke in hypertension.