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目的探讨消栓颗粒对颈动脉粥样硬化斑块的干预效果。方法收集广西贵港市中西医结合骨科医院神经内科确诊为颈动脉粥样硬化斑块的患者共175例为研究对象,采取随机分组法分成观察组和对照组,每组均给予阿司匹林肠溶片100 mg/d+阿托伐他汀钙片20 mg/晚口服,而观察组在上述基础上加用消栓颗粒口服,治疗前、后进行颈动脉超声检测,检测颈动脉粥样硬化内-中膜厚度(IMT)和斑块面积大小,并随访至6个月。结果观察组在降低IMT、缩小主要斑块面积和改善颈动脉狭窄方面均优于对照组;经随访半年未发现新发缺血性脑血管事件。结论消栓颗粒有较好的抗颈动脉粥样硬化作用,与阿司匹林肠溶片、阿托伐他汀钙联合应用可以取得叠加效果,即能更好地改善颈动脉粥样硬化,促进斑块消退,降低动脉狭窄率,对减少脑血管事件的发生获益。
Objective To investigate the effect of Xiaoshang granule on carotid atherosclerotic plaque. Methods A total of 175 patients diagnosed as carotid atherosclerotic plaques in Department of Neurology, Guiyang Hospital of Integrated Chinese and Western Medicine, Guigang City, Guangxi Autonomous Region were enrolled in this study. The patients were randomly divided into observation group and control group. Each group was given aspirin 100 mg / d + atorvastatin calcium tablets 20 mg / night orally, while the observation group on the basis of the above with Xiao Xia particles oral, before and after treatment of carotid ultrasound, detection of carotid atherosclerosis intima-media thickness (IMT) and plaque size, and follow-up to 6 months. Results The observation group was better than the control group in reducing IMT, narrowing the main plaque area and improving carotid stenosis; no ischemic cerebrovascular events were found after 6 months of follow-up. Conclusion Xiaozhu granules has a good anti-carotid atherosclerosis effect, combined with aspirin enteric-coated tablets, atorvastatin calcium can be superimposed to achieve the effect that can better improve carotid atherosclerosis and promote plaque regression , Reduce the rate of arterial stenosis, to reduce the incidence of cerebrovascular events benefit.