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目的:比较研究不同产地雄黄及其炮制品中主成分As2S2及可溶性砷盐As2O3的含量差异。方法:采用2010年版《中国药典》雄黄项下的滴定法测定不同产地雄黄及其炮制品中As2S2的含量,采用AFS-230E型原子荧光光度计检测上述样品中可溶性砷盐As2O3含量。结果:不同产地的雄黄及其炮制品中As2S2,As2O3含量存在显著差异。雄黄炮制后,炮制品中As2S2含量均提高,As2O3含量均明显降低。除吉林和江苏2个产地的的雄黄及其炮制品中As2S2含量<90.0%,其余样品均符合药典规定;且雄黄炮制品中As2O3含量均能控制在1.7 mg.g-1以下。结论:研究结果可为指导雄黄临床合理用药提供参考依据。
OBJECTIVE: To compare the contents of As2S2 and soluble As2O3 in realgar and its processed products from different areas. Methods: The contents of As2S2 in realgar and its processed products from different regions were determined by the titration method of realgar under the 2010 Pharmacopoeia of China Pharmacopoeia. The AFS-230E atomic fluorescence spectrophotometer was used to detect the content of As2O3 in the samples. Results: The contents of As2S2 and As2O3 in realgar and its processed products from different areas were significantly different. After the preparation of realgar, the content of As2S2 in processed products increased and the content of As2O3 decreased obviously. As2S2 content of <90.0% of realgar and its processed products in two places of Jilin and Jiangsu, and the other samples were in line with Pharmacopoeia; and the content of As2O3 in the products of realgar could be controlled below 1.7 mg.g-1. Conclusion: The results of the study can provide a reference for clinical rational drug use.