论文部分内容阅读
采用Border方法制作家兔膜性肾小球肾炎模型，从肾功能与血生化、病理形态定性与定量相结合对比观察分析中药薄芝注射液对家兔膜性肾小球肾炎的治疗作用。结果表明：经治疗后，尿蛋白排出量显著减少，血浆白蛋白逐渐升高，免疫荧光强度明显减弱，肾小球平均直径明显减小，上皮下电子致密沉积物绝对数目由1．11×1010减少到2．63×109，肾小球基底膜厚度由321．34±15．68nm变薄为214．54±7．79nm。各指标和参数治疗前后比较绝大部份具有显著差异（P＜0．05），其差异尤以中西药结合治疗组明显。研究表明薄芝注射液对家兔膜性肾小球肾炎有明显治疗作用，且以中西药结合治疗效果更佳。
Rabbit membranous glomerulonephritis model was made by using Border method. The therapeutic effect of traditional Chinese medicine Bazhi injection on membranous glomerulonephritis in rabbits was analyzed by contrasting the qualitative and quantitative analysis of renal function and blood biochemistry. The results showed that: After treatment, the urinary protein excretion was significantly reduced, serum albumin was gradually increased, the immunofluorescence intensity was significantly weakened, the average diameter of the glomeruli was significantly reduced, the absolute number of subepithelial electron dense deposits from 1.11 × 1010 Reduced to 2.63 × 109, glomerular basement membrane thickness from 321.34 ± 15.68nm thinning to 214.54 ± 7.79nm. Most of the indexes and parameters before and after treatment were significantly different (P <0.05), especially in the combination of traditional Chinese and western medicine treatment group. Studies have shown that thin Zhi injection of rabbit membranous glomerulonephritis significant therapeutic effect, and the combination of Chinese and Western medicine treatment is better.