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喉癌常发生于与汽油、燃料-润滑油物质及其燃烧产物接触的工人中,这可能与汽油蒸气和柴油燃烧后放出的气体中含有3,4苯芘有关。作者曾观察600例喉癌患者,其中41％是汽车司机和机械师。为阐明3,4苯芘和汽油蒸气对喉粘膜的致癌作用,特做如下动物实验。将结晶3,4苯芘溶于加热的葵子油内,做成1％油液,在特制喉镜的明视下,每次用0.2ml,经细金属管向试验动物的喉腔内注入;另法系将试验鼠关在容积为1m~3的密闭室内,使室内汽油蒸气的浓度恒定为150～200mg/m~3。将200只非
Laryngeal cancer often occurs in workers exposed to gasoline, fuel-lubricant substances and their products of combustion, which may be related to the presence of 3,4-pyrene in the gas released by the combustion of gasoline vapors and diesel fuel. The authors have observed 600 cases of laryngeal cancer patients, 41% of them were car drivers and mechanics. In order to elucidate the carcinogenic effects of 3,4-benzenepyrene and gasoline vapor on the laryngeal mucosa, the following animal experiments were made. The crystalline 3,4 benzene pyrene dissolved in heated sunflower oil, made of 1% oil, under the special laryngoscope under the eyes, each with 0.2ml, the fine metal tube to the experimental animals injected into the throat of ; The other law will test rats in a closed volume of 1m ~ 3 closed room, the concentration of indoor gasoline vapor constant 150 ~ 200mg / m3. Will be 200 only