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目的研究中药辅助治疗急性胰腺炎的临床疗效。方法 64例急性胰腺炎患者,随机分成对照组和治疗组,各32例。对照组给予禁食、持续肠胃减压、抑酸、抑制胰腺分泌、防治水电解质紊乱等内科综合治疗;治疗组在对照组内科综合治疗的基础上给予中药胃管内注入或口服。观察两组患者的临床治疗效果,并于治疗前后比较两组血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)等水平。结果治疗组治疗总有效率为90.63%,高于对照组的68.75%,差异具有统计学意义(P<0.05)。治疗前,两组患者血清CRP、IL-6、IL-10水平比较差异均无统计学意义(P>0.05)。治疗后,两组胰腺炎患者血清CRP、IL-6、IL-10均较治疗前显著下降,且治疗组下降更明显,差异有统计学意义(P<0.05)。结论中药辅助常规内科综合治疗急性胰腺炎能快速清除炎症因子,起到多靶点干预治疗的作用,提高了临床疗效,值得临床推广。
Objective To study the clinical efficacy of traditional Chinese medicine in the treatment of acute pancreatitis. Methods 64 cases of acute pancreatitis were randomly divided into control group and treatment group, 32 cases in each. Control group was given fasting, continuous gastrointestinal decompression, acid suppression, inhibition of pancreatic secretion, prevention and treatment of water and electrolyte disorders and other comprehensive medical treatment; the treatment group in the control group on the basis of comprehensive medical treatment given to the traditional Chinese medicine instillation or oral administration. The clinical effects of the two groups were observed. The levels of serum C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-10 (IL-10) were compared before and after treatment. Results The total effective rate of the treatment group was 90.63%, which was higher than that of the control group (68.75%), the difference was statistically significant (P <0.05). Before treatment, serum CRP, IL-6 and IL-10 levels in both groups showed no significant difference (P> 0.05). After treatment, the serum levels of CRP, IL-6 and IL-10 in two groups of patients with pancreatitis decreased significantly compared with those before treatment, and the treatment group decreased more obviously with a significant difference (P <0.05). Conclusion Traditional Chinese medicine combined with conventional medical comprehensive treatment of acute pancreatitis can quickly remove inflammatory factors, play a multi-target intervention and improve clinical efficacy, it is worth clinical promotion.