六价铬对鼠伤寒沙门氏菌的致突变性

• 作 者: 林锦炎 许宏建 梁雪梅 陈光华
• 机 构: 广东省卫生防疫站,广东省卫生防疫站,广东省卫生防疫站,广东省卫生防疫站
• 出 处: 广东卫生防疫
• 发表日期: 1987年02期
• 关键词: 突变性 鼠伤寒沙门氏菌 诱变性 毒理学研究 致突变物 微粒体酶 Ames 致癌性 染色体断裂剂 卫生标准

最近研究揭示了致癌物中有的具有致突变性,致突变物中多数有致癌性。故应用一种敏感的、快速的检测方法来识别与人类有关的致突变物质,认识其潜在的危害,具有一定的实用价值。为了解在水体中六价铬的诱变性,我们选择了鼠伤寒沙门氏菌/哺乳动物肝微粒体酶突变试验(即Ames试验),检测其诱变性及摸索其剂量——反应关系,提供修订地面水六价铬卫生标准的毒理学依据。

Recent studies have revealed that some carcinogens have mutagenicity, mutagens are mostly carcinogenic. Therefore, it is of practical value to use a sensitive and rapid detection method to identify human-related mutagenic substances and recognize their potential hazards. To understand the mutagenicity of hexavalent chromium in water, we selected the Salmonella typhimurium / mammalian microsomal enzyme mutation test (Ames test) to test its mutagenicity and to explore its dose-response relationship, providing an amendment Toxicological Basis for Hygienic Standards of Hexavalent Chromium on Ground Water.