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目的:新辅助化疗前、后Ki67表达的变化情况相关性的临床研究。方法:回顾性研究方法。结果:新辅助化疗后整体Ki67明显降低,有统计学意义。Ki67降低三阴性与非三阴性乳腺癌、组织学Ⅰ、Ⅱ与Ⅲ级之间、MP分级间有统计学意义(P<0.05);。与年龄、月经及淋巴结状态、组织学分类、化疗方案中包含A、T于不含有A、T无相关性(P>0.05);结论:新辅助化疗能够降低Ki67表达并与多因素有关。
OBJECTIVE: To study the correlation between Ki67 expression and neoadjuvant chemotherapy before and after treatment. Methods: Retrospective research methods. Results: The overall Ki67 was significantly lower after neoadjuvant chemotherapy, with statistical significance. Ki67 decreased triple negative and non - triple negative breast cancer histological grade Ⅰ, Ⅱ and Ⅲ, MP grade was statistically significant (P <0.05) ;. There was no correlation between age, menstruation and lymph node status, histological classification, chemotherapy regimen including A, T and no A, T (P> 0.05) .Conclusion: Neoadjuvant chemotherapy can reduce Ki67 expression and is associated with multiple factors.