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目的分析河源地区妊娠中期唐氏综合征(DS)的筛查情况,明确妊娠中期DS筛查对于预防出生缺陷的价值。方法 4000例妊娠中期孕妇,运用时间分辨技术对孕妇血清学生化指标进行检测,并通过四维彩超对孕妇实施超声检查。运用产筛软件对孕妇的胎儿风险进行评估。结果 4000例孕妇进行分组,其中孕周为14~17周2313例,经过唐氏综合征筛查评估232例为高危孕妇,设为高危组;2081例为低危孕妇,设为低危组。孕周为18~20周1687例,其中高危组孕妇166例,低危组孕妇1521例。孕周相同的孕妇,高危组的游离雌三醇(u E3)和甲胎蛋白(AFP)浓度明显比低危组低,并且高危组孕妇的游离人绒毛膜促性腺激素β-亚单位(Free-βHCG)明显比低危组高(P<0.05)。结论通过为孕中期孕妇筛查DS,能够有效避免胎儿出现出生缺陷,从本质上提升出生人口素质,应不断普及和推广妊娠中期DS筛查。
Objective To analyze the screening status of Down Syndrome (DS) in the second trimester of pregnancy in Heyuan region, and clarify the value of DS screening in the second trimester to prevent birth defects. Methods Four thousand pregnant women of the second trimester were enrolled in this study. Serum biochemical markers of pregnant women were detected by time-resolved technique. The pregnant women underwent ultrasonography by four-dimensional ultrasonography. Screening software was used to assess the fetal risk of pregnant women. Results 4,000 pregnant women were divided into groups, of which 2313 were gestational weeks of 14-17 weeks. 232 cases were classified as high-risk group by Down’s syndrome screening, and 2081 were low-risk pregnant women. 1687 gestational weeks for 18 to 20 weeks, of which 166 cases of high-risk group of pregnant women, pregnant women in low-risk group 1521 cases. The gestational age of the same pregnant women, high-risk group of free estriol (u E3) and AFP levels were significantly lower than the low-risk group, and high-risk group of pregnant women free human chorionic gonadotropin β-subunit -βHCG) was significantly higher than the low-risk group (P <0.05). Conclusion Screening DS for pregnant women during the second trimester can effectively prevent the occurrence of birth defects in the fetus and essentially enhance the quality of the birth population. DS screening should be popularized and popularized in the second trimester of pregnancy.