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用绵羊红细胞（ＳＲＢｃ）免疫大鼠，在免疫后第３天至第６天，使用光电比色法检测大鼠海马、下丘脑、丘脑、中脑和脑桥内乙酰胆碱酯酶（ＡＣｈＥ）活性的变化。结果表明，海马和下丘脑中ＡＣｈＥ活性在免疫后第３天至第６天均显著低于对照组；而丘脑、中脑和脑侨内ＡＣｈＥ活性与对照组比较均无明显差异。由此提示：在体液免疫应答期间，海马和下丘脑中ＡｃｈＥ活性降低，亦即以上两脑区中乙酰胆碱（ＡＣｈ）含量可能增加。我们以往的实验说明，中枢ＡＣｈ可调节体液免疫应答。综合两者结果，可以推测在中枢ＡＣｈ与免疫之间存在着相互作用。
Rats were immunized with sheep red blood cells (SRBc). Changes of acetylcholinesterase (AChE) activity in rat hippocampus, hypothalamus, thalamus, midbrain and pons after 3 days to 6 days of immunization were detected by photochromic assay . The results showed that AChE activity in the hippocampus and hypothalamus was significantly lower than that in the control group on the 3rd day to the 6th day after immunization. There was no significant difference in AChE activity in the thalamus, midbrain and brain between the control group and the control group. This suggests that during humoral immune response, AchE activity in the hippocampus and hypothalamus is reduced, ie, acetylcholine (ACh) levels may increase in both brain regions. Our previous experiments showed that central ACh regulates the humoral immune response. Taken together, we can speculate that there is an interaction between central ACh and immunity.