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目的探讨小剂量左旋甲状腺辅助治疗扩张性心肌病合并顽固性心力衰竭的疗效及可能作用机制。方法入选因扩张性心肌病难治性心力衰竭同时合并有甲状腺功能正常的病态综合征在本院心内科住院的患者共110例,随机分为小剂量左旋甲状腺治疗组及常规治疗组各55例,比较两组治疗效果。结果两组心率均较治疗前减慢,治疗组减慢更明显,较对照组减慢5次以上,差异有统计学意义;饮食、精神、6m in步行距离,治疗组均较对照组改善明显、迅速;住院时间明显缩短,差异有统计学意义;12周时,左室射血分数治疗组较对照组改善明显,差异有统计学意义;28周时,左室射学分数和左室大小,治疗组较对照组均改善明显,差异有统计学意义。结论小剂量左旋甲状腺素治疗扩张性心肌病伴甲状腺功能正常的病态综合征有效。
Objective To investigate the efficacy and possible mechanism of low-dose levothyroid-thyroid adjuvant therapy for patients with dilated cardiomyopathy complicated with refractory heart failure. Methods A total of 110 hospitalized patients with cardiomyopathy who had refractory heart failure due to dilated cardiomyopathy with normal thyroid function were randomly divided into low-dose L-thyroid treatment group and 55 cases in conventional treatment group , Comparing the treatment effect of two groups. Results The heart rate of the two groups was slower than that of the control group before treatment, the treatment group slowed down significantly more than the control group more than 5 times, the difference was statistically significant; diet, mental, 6m in walking distance, the treatment group improved significantly compared with the control group , Fast; hospitalization time was significantly shorter, the difference was statistically significant; 12 weeks, left ventricular ejection fraction treatment group compared with the control group improved significantly, the difference was statistically significant; 28 weeks, left ventricular fractional and left ventricular size , The treatment group than the control group were significantly improved, the difference was statistically significant. Conclusion Low-dose levothyroxine is effective in treating dilated cardiomyopathy with pathological syndrome with normal thyroid function.