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目的:分析沧州地区PCOS患者子宫内膜HOXA10、LIF及血清IL-6的表达情况,探讨其对妊娠结局的影响。方法:随机选取我院近年来收治入院的36例PCOS患者(观察组)及36例非PCOS不孕症患者(对照组)作为研究对象,测定患者分泌中期及增生期子宫内膜HOXA10、LIF及血清IL-6,进行对比分析。结果:观察组患者子宫内膜HOXA10、LIF及血清IL-6表达在分泌中期及增生期均显著低于对照组患者,P<0.05,有统计学意义。结论:PCOS患者子宫内膜HOXA10、LIF及血清IL-6的低表达是导致患者不孕及反复流产的主要原因,对三者的协同检查为PCOS不孕患者的诊治提供了新方向。
Objective: To analyze the expression of endometrial HOXA10, LIF and serum IL-6 in patients with PCOS in Cangzhou and to explore its effect on pregnancy outcome. Methods: 36 cases of PCOS (observation group) and 36 cases of non-PCOS infertility (control group) admitted to our hospital in recent years were randomly selected as research object to measure the secretion of endometrial HOXA10, LIF and Serum IL-6, for comparative analysis. Results: The expression levels of HOXA10, LIF and IL-6 in the endometrium of the observation group were significantly lower than those of the control group in the middle stage and the proliferative stage, respectively (P <0.05, statistically significant). Conclusion: The low expression of endometrial HOXA10, LIF and serum IL-6 in patients with PCOS is the main reason leading to infertility and repeated miscarriage. The collaborative examination of the three provides a new direction for the diagnosis and treatment of PCOS infertility.