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自1964年Epstein等人从Burkitt淋巴瘤中检出了EB病毒后,该病毒被认为是致癌性疱疹病毒中的一种。一、EB病毒颗粒、相关抗原、基因组的结构及性状 EB病毒为20面体,其衣壳有162个壳粒,直径为150nm,分子量1.15×10~8道尔顿,含线状双股DNA。 EB病毒感染后产生数种抗原,主要可用荧光抗体法检出。 (1)衣壳抗原(VCA);是以160K为主的数种多肽,属晚期蛋白;(2)早期抗原(EA):是EB病毒感染时最早出现的抗原,
Since Epstein et al detected Epstein-Barr virus in Burkitt’s lymphoma in 1964, the virus is thought to be one of the oncogenic herpesviruses. I. Epstein-Barr Virus Particles, Related Antigens, Genomic Structure and Traits Epstein-Barr virus is a 20-sided body with 162 capsid capsids, 150 nm in diameter, and a molecular weight of 1.15 × 10 -8 Daltons containing linear double-stranded DNA. Epstein-Barr virus infection produces several antigens, mainly detected by fluorescent antibody method. (1) Capsid antigen (VCA); It is a polypeptide mainly composed of 160K, belonging to advanced protein. (2) Early antigen (EA): The earliest antigen appeared when Epstein-