论文部分内容阅读
设计合成了溴基功能化的赖氨酸单体(Br-lys)并通过关环反应制备了对应的溴代L-赖氨酸N-羧酸酐(Br-Lys-NCA)单体.利用过渡金属引发剂Ni(COD)depe调控的NCA活性开环聚合和顺序添加单体的方法,得到了组成和结构明确的聚(ε苄氧羰基L-赖氨酸)-b-PBrLL(PZLL-PBrLL)两嵌段共聚肽.利用PZLL-b-PBrLL两嵌段共聚肽为大分子引发剂,通过ATRP引发甲基丙烯酸寡聚乙二醇酯(EGMA),合成了以聚赖氨酸为骨架的牙刷状分子刷.研究发现PZLL-PBrLL两嵌段在四氢呋喃中形成α-螺旋结构,螺旋度随着PBrLL链段的增长而降低,而PZLL-b-(PBrLL-g-PEGMA)形成部分α-螺旋构象,螺旋度随侧链PEGMA增长而减小.
The bromine-functionalized lysine monomer (Br-lys) was designed and synthesized and the corresponding brominated L-lysine N-carboxylic anhydride (Br-Lys-NCA) Poly (ε-benzyloxycarbonyl L-lysine) -b-PBrLL (PZLL-PBrLL) was obtained by the ring-opening polymerization of NCA with the metal initiator Ni (COD) depe and sequential addition of monomers. ) Diblock copolymer peptide.Using PZLL-b-PBrLL diblock copolymer as macroinitiator, ATRP initiated oligomerization of ethylene glycol monomethacrylate (EGMA) Toothbrush-like molecular brush.The study found that the PZLL-PBrLL diblock forms an α-helical structure in tetrahydrofuran, the degree of helicity decreases with the increase of the PBrLL segment, while the part of α- The helical conformation and degree of helicity decrease with the increase of side chain PEGMA.