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目的 :探讨脆性组氨酸三联体 (FHIT)基因和p5 3基因在胃癌中的表达及其与临床病理因素的关系。方法 :采用免疫组化SP法检测 78例胃癌组织中FHIT和p5 3的表达。结果 :FHIT和 p5 3在胃癌中表达率分别为 4 3.6 %和 5 2 .6 %。FHIT蛋白的丢失在胃癌中占 5 6 .4 % ,两者与胃癌的组织类型、浸润深度、临床分期和淋巴结转移状况无关 (P >0 .0 5 )。结论 :①胃癌组织中FHIT蛋白的丢失是频发事件 ,FHIT可能是胃癌发生中重要的候选抑癌基因 ;②测定FHIT和p5 3的表达 ,可用于高危人群的筛选
Objective: To investigate the expression of FHIT gene and p5 3 gene in gastric cancer and its relationship with clinicopathological factors. Methods: The expression of FHIT and p5 3 in 78 cases of gastric cancer was detected by immunohistochemical SP method. Results: The expression rates of FHIT and p5 3 in gastric cancer were 43.6% and 52.6%, respectively. The loss of FHIT protein in gastric cancer accounted for 56.4%, which was not related to the histological type, depth of invasion, clinical stage and lymph node metastasis (P> 0.05). Conclusion: (1) The loss of FHIT protein in gastric cancer is a frequent event, and FHIT may be an important candidate tumor suppressor gene in gastric carcinogenesis. (2) The expression of FHIT and p5 3 can be used in the screening of high risk population