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目的：观察托吡酯（商品名妥泰，ＴＰＭ）单药治疗小儿不同类型癫 发作的疗效及不良反应。方法：单独应用ＴＰＭ治疗４０例临床诊断的小儿癫 患者（部分性发作１３例，Ｌｅｎｎｏｘ－Ｇａｓｔａｕｔ综合征１３例，Ｗｅｓｔ综合征１１例，青少年肌阵挛３例），治疗前后进行自身对照的开放性研究。平均治疗６个月，记录癫 发作频率变化及副作用。结果：本组４０例中发作减少≥５０％为８２％，发作消失４７％，其中部分性发作、Ｌｅｎｎｏｘ－Ｇａｓｔａｕｔ综合征、Ｗｅｓｔ综合征发作消失分别为 ６１％、４６％、２７％，发作减少 ５０％者分别为９２％、６９．３％及８２％。青少年肌阵挛３例，发作减少≥７５％为３例，其中２例发作消失。不良反应为纳差１２．５％，嗜睡５％，无汗症１０％。结论：ＴＰＭ单药治疗小儿部分发作性癫 、Ｌｅｎｎｏｘ－Ｇａｓｔａｕｔ综合征、Ｗｅｓｔ综合征及青少年肌阵挛性癫 有效，与同期ＴＰＭ添加治疗组疗效相仿，不良反应少于添加治疗组。
Objective: To observe the efficacy and side effects of topiramate (TPT) monotherapy in treating different types of epilepsy in children. METHODS: Forty cases of clinically diagnosed pediatric epilepsy (13 partial, 13 Lennox-Gastaut syndrome, 11 West syndrome, and 3 myoclonus in adolescents) were treated with TPM alone. The self-control was performed before and after treatment Sexual research. The average treatment for 6 months, recording changes in seizure frequency and side effects. Results: In the 40 cases, the reduction of seizure was 82% and the seizure disappeared by 47%. The partial seizures, Lennox-Gastaut syndrome and West syndrome disappeared were 61%, 46% and 27% 50% were 92%, 69.3% and 82% respectively. 3 cases of young myoclonus, episodes of ≥75% reduction in 3 cases, of which 2 cases disappeared. Adverse reactions were 12.5% with anorexia, 5% lethargy and 10% with no perspiration. Conclusion: TPM monotherapy in children with partial epilepsy, Lennox-Gastaut syndrome, West syndrome and adolescent myoclonic epilepsy, with the same effect of TPM added the same treatment group, adverse reactions less than adding the treatment group.