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HIF-1α是与恶性肿瘤生长进程密切相关的转录调节因子,瘤细胞氧状态及基因变异共同调控HIF-1α表达水平及其活性。HIF-1α高表达在人体恶性肿瘤中广泛存在。HIF-1α高表达对肿瘤组织放化疗敏感性有显著影响,体外实验表明针对HIF-1α的靶向药物和基因治疗能够通过主动下调HIF-1
HIF-1α is a transcriptional regulator closely related to the growth of malignant tumor. The expression of HIF-1α and the activity of HIF-1αare co-regulated by the oxygen status of tumor cells and gene mutation. HIF-1α overexpression is widespread in human malignancies. HIF-1α overexpression has a significant effect on the chemosensitivity of tumor tissue. In vitro experiments showed that the targeted drugs and gene therapy targeting HIF-1α could down-regulate the expression of HIF-1