论文部分内容阅读
目的:探讨海水浸泡胸部开放伤致急性肺损伤的特点,为研究救治方案提供依据.方法:实验动物致伤后随机分为单纯胸外伤组(n=10)和海水浸泡组(n=10).海水浸泡组动物于伤后置入人工配制的海水中,于伤前及入水后0.5、1、2、3和4h取血测定TNFa和IL-Iβ变化,同时监测血液动力学、呼吸系统和动脉血气变化.活杀或死后立即取肺标本行光镜和电镜检查.单纯胸外伤组除不浸泡海水外处理同海水浸泡组.结果:海水浸泡组死亡率明显高于单纯胸外伤组,并且生存时间明显短于单纯胸外伤组,平均生存时间为45min.海水浸泡组的急性肺损伤明显重于单纯胸外伤组,表现在严重的低氧血症和高碳酸血症、肺含水量明显增加、血浆TNFa和IL-Iβ伤后明显升高并且高峰时间明显提前.结论:海水浸泡加剧胸外伤致急性肺损伤的程度,导致呼吸及循环系统进行性衰竭,加速实验动物死亡.
Objective: To investigate the characteristics of acute lung injury caused by open chest injury in seawater so as to provide a basis for the study of treatment.Methods: The experimental animals were randomly divided into simple thoracic injury group (n = 10) and seawater immersion group (n = 10) The animals in the seawater immersion group were placed in artificial seawater after injury, and the changes of TNFa and IL-1β were measured at 0.5, 1, 2, 3 and 4h after injury and at the same time monitoring the hemodynamics, respiratory system and Arterial blood gas changes.One day after the killing or death of lung specimens taken by light microscopy and electron microscopy chest thoracic injury group in addition to not soaked seawater treatment with seawater immersion group.Results: seawater immersion group mortality was significantly higher than simple thoracic injury group, And the survival time was significantly shorter than simple thoracic injury group, the average survival time was 45min.A seawater immersion group of acute lung injury was significantly more than simple thoracic injury group, manifested in severe hypoxemia and hypercapnia, lung water content was significantly Increased, plasma TNFa and IL-1β significantly increased after injury and the peak time was significantly earlier.Conclusion: Seawater immersion aggravate the extent of acute lung injury caused by thoracic injury, leading to respiratory failure and circulatory system failure, accelerating the death of experimental animals.