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在印度Shahjahanpur地区现有的体内检测方法,不仅费时,且需于治疗后一周,逐日加以追查。本文报道应用简化的方法检测47例恶性疟患者对氯喹敏感性的结果。体内试验是一种既简单又实用的方法,优于体外试验方法。试验对象均为发热病人,外周血涂片均查到恶性疟原虫环状体,并用Dill和Glazko法尿检氯喹阴性。试验时,每一病人口服600mg氯喹磷酸盐,14岁以下者则按10mg/kg体重的剂量用药,治疗前再次血栓以确定每mm~3血液中无性体疟原虫的密度。涂片的当天用药即d0,次日(d1)再服相同量的氯喹,d2按半量即300mg剂量
Existing in-vivo testing methods in Shahjahanpur, India, are not only time-consuming but need to be traced daily, one week after treatment. This article reports the results of a simplified method for detecting susceptibility to chloroquine in 47 patients with falciparum malaria. In vivo testing is a simple and practical method that outperforms in vitro testing methods. All subjects were febrile patients, peripheral blood smear were found in P. falciparum ring, and Dill and Glazko urine test for chloroquine negative. Each patient was orally administered with 600 mg of chloroquine phosphate, and those under 14 years of age were given doses of 10 mg / kg of body weight. Thrombosis was repeated before treatment to determine the density of P. falciparum per mm-3 of blood. Smear the same day medication d0, the next day (d1) and then serve the same amount of chloroquine, d2 by half the amount of 300mg dose