抗心律失常药:吡美诺

• 作 者: Reier M.J 吕国良
• 出 处: 药学情报通讯
• 发表日期: 1986年03期
• 关键词: 吡美诺 浦肯野氏纤维 动作电位振幅 抗心律失常药 动作电位 上升速率 除极 盐酸 室性心律失常 化学结构式

盐酸吡美诺(Pirmenol)是一种吡啶甲醇衍生物,其化学结构式: 在狗心脏分离出的浦肯野氏纤维实验中,观察到吡美诺是有抑制最大的O相除极上升速率,降低动作电位振幅,并减慢传导速度。50％再极化时测定的动作电位持续时间缩短,但在整个再极化时的动作电位持续期间和有效不应期则延长。因此吡美诺具有

Pirmenol hydrochloride is a pyridinemethanol derivative whose chemical structure: In the Purkinje fiber test isolated from the dog’s heart, it was observed that pimecline was the most inhibited O phase decoupling rate, Reduce the amplitude of the action potential and slow down the conduction velocity. The duration of the action potential measured at 50% repolarization was shortened but the duration of the action potential and the effective refractory period were extended over the entire period of the repolarization. So Pyrimethamine has