论文部分内容阅读
目的探讨后程适形放射治疗(3dimensional comformal radiation therapy,3D-CRT)同步化学疗法治疗Ⅲ期非小细胞肺癌(non-small-cell lung cancer,NSCLC)的近期疗效。方法搜集2005年1月2008年6月NSCLC患者共115例,其中53例行单纯后程3D-CRT(单放组),62例行后程3D-CRT联合同步化学疗法(联合组),所有患者均经病理证实为Ⅲ期NSCLC。两组放射治疗方案均采用常规分割治疗加后程3D-CRT,DT 62～72Gy。联合组化学疗法采用TP(紫杉醇+顺铂)方案。结果单放组和联合组近期疗效(完全缓解+部分缓解)分别为75.47%、91.94%,差异有统计学意义(P<0.05)。单放组和联合组的治疗不良反应主要有白细胞、血小板减少,放射性食管炎,放射性气管炎,恶心、呕吐等胃肠道反应。骨髓抑制和消化道反应,联合组稍高于单放组。经对症治疗后,所有患者均可耐受。结论后程3D-CRT联合TP方案化学疗法较单纯后程适形放射治疗明显提高Ⅲ期NSCLC近期疗效。患者耐受性尚可。
Objective To investigate the short-term curative effect of concurrent chemotherapy of late-course conformal radiation therapy (3D-CRT) for stage Ⅲ non-small-cell lung cancer (NSCLC). Methods A total of 115 NSCLC patients were collected from January 2005 to June 2008. Of them, 53 patients underwent 3D-CRT (single group) and 62 patients underwent 3D-CRT combined with synchronous chemotherapy (combined group) All patients were pathologically confirmed as stage III NSCLC. The two groups of radiotherapy programs were treated with conventional segmentation plus 3D-CRT, DT 62 ~ 72Gy. Combination chemotherapy with TP (paclitaxel + cisplatin) program. Results The immediate curative effect (complete remission + partial remission) in the radiotherapy group and the combination group was 75.47% and 91.94%, respectively, with significant difference (P <0.05). Adverse reactions of radiotherapy alone and combination therapy include leukopenia, thrombocytopenia, radiation esophagitis, radiation bronchitis, nausea and vomiting. Myelosuppression and gastrointestinal reactions, combined group slightly higher than the single group. After symptomatic treatment, all patients can tolerate. Conclusions The posterior procedural 3D-CRT combined with TP regimen significantly improves the short-term response to stage III NSCLC compared with simple posterior conformal radiation therapy. Patient tolerance is acceptable.