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肼是肼类化合物中毒性最大,而且在过去的体内研究中发现对肝脏的损伤也是最强的化合物。某些作者报道动物肼中毒后血浆ALT活性及BSP潴留率均有明显升高,而有些作者如Killane及Sass等则报道肼在体内及体外都明显地抑制ALT活性。本文采用大鼠离体肝脏灌流作为实验模型,用不同剂量肼灌流大鼠离体肝脏,观察了不同时间的乳酸、丙酮酸、ALT、LDH、BSP、K~+、Na~+及总蛋白的变化。结果表明,100ml灌流液含1.5
Hydrazine is the most toxic of hydrazines, and in the past in vivo studies found that the damage to the liver is also the strongest compound. Some authors have reported significant increases in plasma ALT activity and BSP retention after hydrazine poisoning in animals, while some authors, such as Killane and Sass, reported that hydrazine significantly inhibits ALT activity both in vivo and in vitro. In this study, isolated rat liver perfusion was used as an experimental model, and the isolated rat liver was perfused with different doses of hydrazine. The contents of lactate, pyruvate, ALT, LDH, BSP, K ~ +, Na ~ + and total protein Variety. The results showed that, 100ml perfusion fluid containing 1.5