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支气管哮喘的发病机制涉及急性、慢性炎症。尽管这些炎症的确切机制还不很清楚,但有理由认为免疫调节剂可能对哮喘有益。秋水仙素能与管蛋白结合,从而改变微管的聚集产生一系列抗炎作用,包括抑制细胞的运动和分泌过程。本文作者研究了过敏性哮喘患者口服秋水仙素对IgE介导的速发和迟发气遭反应的影响以及相关的非特异性气道反应性改变。 实验方法 选择12例特异性过敏患者,年龄28～40岁,男女各6例,均有对豚草过敏的哮喘史。实验分
The pathogenesis of bronchial asthma involves acute, chronic inflammation. Although the exact mechanism of these inflammation is not well understood, it is reasonable to assume that immunomodulators may be beneficial for asthma. Colchicine binds to the integrin and thus alters the assembly of microtubules to produce a series of anti-inflammatory effects, including inhibition of cell motility and secretion. The authors investigated the effect of oral colchicine on allergic asthma patients on IgE-mediated immediate and delayed gas response and related non-specific airway reactivity changes. Experimental Methods Twelve patients with specific allergy were selected, aged from 28 to 40 years old, 6 males and 6 females, all of whom had a history of allergic asthma to ragweed. Experimental points