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我院对50例晚期肺癌病人进行了支气管动脉灌注化疗(简称BAI),其中23例加用小剂量全身化疗,並对两组的疗效进行了对比观察。 50例晚期肺癌(Ⅲ期27例、Ⅳ期23例)均经病理及细胞学检查证实,其中鳞癌24例,腺癌16例,小细胞癌7例,混合癌3例;中心型肺癌41例,周围型肺癌9例。 两组病例在BAI时均用丝裂霉素8～12mg,顺铂40～60mg,灌注1～6次(多数为2～3次)。单纯BAI组灌注间隔为3周;BAI加小剂量全身化疗组BAI间隔为4～5周,其间加小剂量全身化疗1～2周,並针对不同组织类型在抗癌药物上有所选择。两组均在治疗前及结束时摄胸片对比,以评价
In our hospital, 50 cases of advanced lung cancer patients underwent bronchial arterial infusion chemotherapy (BAI for short), of which 23 cases were treated with low-dose systemic chemotherapy, and the efficacy of the two groups was compared. 50 cases of advanced lung cancer (27 cases in stage III and 23 cases in stage IV) were confirmed by pathological and cytological examinations, including 24 cases of squamous cell carcinoma, 16 cases of adenocarcinoma, 7 cases of small cell carcinoma, 3 cases of mixed carcinoma, and 41 cases of central lung cancer. Cases, 9 cases of peripheral lung cancer. In both groups, mitomycin C was used as 8 to 12 mg and cisplatin was used as 40 to 60 mg for 1 to 6 infusions (mostly 2 to 3). The interval of perfusion in BAI group was only 3 weeks. The interval of BAI in BAI plus low-dose systemic chemotherapy group was 4 to 5 weeks. During this time, low-dose systemic chemotherapy was added for 1 to 2 weeks, and the anti-cancer drugs were selected for different tissue types. The two groups were compared before and at the end of the treatment to evaluate the chest radiograph.