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目的观察ＬＢＮＰ对２１ｄＨＤＴ－６°卧床模拟失重所致立位耐力不良的对抗效果。方法１２名健康男性青年志愿者，进行２１ｄＨＤＴ－６°卧床实验。随机分为对照组和下体负压组，每组６人。与对照组不同，下体负压组在最后一周，每天进行１ｈ、－４．０ｋＰａ的下体负压锻炼。结果卧床前，１２名受试者顺利通过７５°、２０ｍｉｎ立位耐力检查。卧床第１０ｄ立位耐力检查时，对照组有５人、ＬＢＮＰ组有４人出现晕厥前或晕厥症状，两组平均耐受时间均低于卧床前（Ｐ＜０．０５）；第２１ｄ时，对照组有５人未通过，平均耐受时间较卧床前显著降低（Ｐ＜０．０５）；而ＬＢＮＰ组有１人未通过，平均耐受时间显著高于对照组（Ｐ＜０．０５）。结论２１ｄ头低位卧床后立位耐力显著降低。下体负压能够有效对抗头低位卧床导致的立位耐力降低。
Objective To observe the antagonistic effect of LBNP on the standing stamina induced by simulated weightlessness on 21dHDT-6 °. Methods Twelve healthy male volunteers underwent 21-day HDT-6 ° bed rest. Randomly divided into control group and lower body negative pressure group, 6 in each group. Different from the control group, the lower body negative pressure group in the last week, daily 1h, -4.0kPa lower body negative pressure exercise. Results Bedridden, 12 subjects passed 75 °, 20min standing endurance test. In the end of the 10th day of bed rest, there were 5 in the control group and 4 in the LBNP group, with pre-syncope or syncope symptoms. The mean duration of time to two groups was lower than that before bed rest (P <0.05) Five patients in the control group failed to pass the test, and the average duration of resistance was significantly lower than that in the bed (P <0.05). One patient in the LBNP group did not pass the test and the mean duration of tolerance was significantly higher than that in the control group (P <0.05) . Conclusions 21d head down bed position significantly reduced endurance. Lower body negative pressure can effectively combat the head-lying bed caused by reduced standing stamina.