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目的检测骨营养素作为保健食品的安全性。方法依据卫生部《保健食品检验与评价技术规范》,通过小鼠经口急性毒性试验、致突变试验,大鼠30 d喂养试验对骨营养素进行检测。结果小鼠经口LD50>21.5 g/kg,属无毒级物质;致突变试验结果为阴性;大鼠30 d喂养试验表明,各剂量组体重增长、食物利用率、脏体比、血液学及血清生化指标与对照组比较均无显着性差异(P>0.05),通过病理检查,主要脏器未发现与实验有关的病变。结论骨营养素为无毒、无致突变作用的保健食品。
Objective To test the safety of bone nutrient as health food. Methods According to the Ministry of Health “health food inspection and evaluation technical specifications”, by oral acute toxicity test in mice, mutagenicity test, rat 30 d feeding test for bone nutrient testing. Results The oral LD50> 21.5 g / kg in mice was a non-toxic substance. The result of mutagenicity test was negative. The experiment of feeding for 30 days in rats showed that body weight gain, food utilization rate, There was no significant difference between the serum biochemical indexes and the control group (P> 0.05). No pathological changes were found in the major organs through pathological examination. Conclusion Bone nutrients are non-toxic, non-mutagenic health food.