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目的:观察经静脉溶栓治疗急性心肌梗死(AMI)患者,梗死相关血管(IRA)再通早晚与其心肌梗死面积之关系。方法;选取经溶栓后IRA再灌流患者71例,发病2~3周行99mTC-MIBI心肌断层显像测定AMI梗死范围指数,二维超声测定在室射血分数(LVEF)。结果:1)57例距发病≤6hIRA再通患者的梗死范围指数低于14例>6h组(0.326±0.075比0.373±0.071,P<0.05);2)梗死范围指数与LVEF中度相关(r=0.5139,P<0.001)。结论:AMI患者静脉溶栓治疗IRA早开通比晚开通者的心梗范围缩小,心功能得到更好保护。
OBJECTIVE: To observe the relationship between infarct-related vascular (IRA) recanalization and myocardial infarct size in patients with acute myocardial infarction (AMI) treated by intravenous thrombolysis. Methods Thirty-one patients with IRA reperfusion after thrombolysis were enrolled. AMI infarct extent index was measured by 99mTC-MIBI myocardial perfusion imaging 2 to 3 weeks after the onset of thrombolysis. The LVEF was measured by two-dimensional ultrasound. Results: 1) The infarct index of 57 patients with relapsed from 6 h IRA was lower than that of 14 patients> 6h (0.326 ± 0.075 vs 0.373 ± 0.071, P <0.05); 2) The infarct size index was moderately correlated with LVEF (r = 0.5139, P <0.001). Conclusions: The AMI patients with thrombolytic therapy of IRA early open than the late open myocardial infarction narrowed the scope of the heart function better protected.