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目的:研究益气化痰活血法联合西医治疗对肺间质纤维化患者氧化应激反应及炎症因子的影响。方法:将83例肺间质纤维化患者随机分为治疗组及对照组。两组患者均采用常规西医治疗,包括抗感染及使用激素。治疗组在此基础上加用益气化痰活血方。两组患者以3个月为1个疗程。1个疗程后评价疗效。结果:疗程结束时两组患者在肺活量(VC)、用力肺活量(FVC)及1秒用力呼气容积(FEV1)/用力肺活量(FVC)比值较治疗前均有所提高(P<0.01);而疗程结束时,治疗组VC、FVC及FEV1/FVC明显高于对照组(P<0.01),治疗组GSH-Px及CAT水平均明显高于对照组(P<0.01),治疗组LPO水平低于对照组(P<0.01),而治疗组在支气管肺泡灌洗液及血清中TNF-α水平均明显低于对照组(P<0.01)。结论:在西医治疗的基础上加用益气化痰活血方可改善肺间质纤维化患者体内异常氧化应激状态及肿瘤坏死因子水平,改善肺功能。
Objective: To study the effects of Yiqi Huatan Huoxue combined with Western medicine on oxidative stress and inflammatory factors in patients with pulmonary fibrosis. Methods: 83 patients with interstitial fibrosis were randomly divided into treatment group and control group. Both groups of patients were treated with conventional Western medicine, including anti-infectives and hormones. On the basis of this, the treatment group added Yiqi Huatan Huoxue Recipe. Two groups of patients to 3 months for a course of treatment. After a course of evaluation of efficacy. Results: The VC, FVC and FEV1 / FVC ratio of the two groups were significantly higher than those before treatment (P <0.01) at the end of the course of treatment. At the end of treatment, the levels of VC, FVC and FEV1 / FVC in the treatment group were significantly higher than those in the control group (P <0.01). The levels of GSH-Px and CAT in the treatment group were significantly higher than those in the control group (P <0.01) (P <0.01). However, the levels of TNF-α in bronchoalveolar lavage fluid and serum in the treatment group were significantly lower than those in the control group (P <0.01). Conclusion: Based on the Western medical treatment, it can improve abnormal oxidative stress status and tumor necrosis factor level and improve pulmonary function in patients with interstitial fibrosis of the lungs.