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目的:探讨保守治疗早发性重度子痫前期对妊娠结局的临床作用。方法:2009年9月～2010年9月34例早发性重度子痫前期患者,采取解痉、镇静、降压、促胎儿肺成熟、降颅压或利尿、改善微循环等保守治疗,分析孕妇并发症发生情况及围生儿结局。结果:34例中4例(11.7%)发生低蛋白血症,3例(8.8%)发生肝肾损害,2例(5.9%)发生胎儿窘迫,2例(5.9%)发生胎盘早剥,1例(2.9%)发生HELLP综合征,1例(2.9%)发生心衰;2例(5.9%)发生胎儿窘迫死亡,4例(11.8%)发生新生儿窒息,其中2例(5.9%)经抢救无效死亡。结论:重度子痫是母婴死亡的主要原因之一,在早发性重度子痫前期根据病情综合分析、权衡利弊采取及时的保守治疗方式,对改善母婴结局有重要的临床意义。
Objective: To investigate the clinical effect of conservative treatment of early-onset severe preeclampsia on pregnancy outcome. Methods: From September 2009 to September 2010, 34 patients with early-onset severe preeclampsia were treated with antispasmodic therapy, sedation, antihypertensive therapy, accelerated fetal lung maturation, intracranial pressure reduction or diuresis, and microcirculation therapy. Maternal complications and perinatal outcome. Results: Hypoproteinemia occurred in 4 of 34 (11.7%), liver and kidney lesions in 3 (8.8%), fetal distress in 2 (5.9%) and placental abruption in 2 (5.9%) and 1 HELLP syndrome occurred in 1 case (2.9%) in 2 cases (5.9%), fetal distress in 2 cases (5.9%), neonatal asphyxia in 4 cases (11.8%), and in 2 cases Rescue invalid death. Conclusion: Severe eclampsia is one of the major causes of maternal and infant death. Premature severe preeclampsia has important clinical significance in improving the outcome of maternal and infant according to the comprehensive analysis of the condition and weighing the pros and cons to take timely and conservative treatment.