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据临床观察,中药平消片(原名P235)对治疗恶性肿瘤有一定效果,尤其是对中晚期肺癌患者,有缓解症状、延长存活时间之效,对部分病人的肿瘤还有缩小甚至消退作用。实验研究证明,平消片对小鼠艾氏腹水癌及肉瘤S180有抑制作用。为了进一步探讨其作用原理,我们利用氨基甲酸乙酯诱发的小鼠肺腺瘤作为模型,对用药组与不用药组瘤细胞的超微结构进行了观察。实验动物为昆明种小白鼠,6周龄,体重18～22克,分成4组。(1)正常组:12只,腹腔注射生理盐水。(2)对照组:12只,腹腔注射5％氨基甲酸乙酯溶液,剂量为1.0毫克/克体重。(3)平消片组:13只,腹腔注射平消
According to clinical observation, traditional Chinese medicine Pingxiao Tablets (formerly known as P235) has a certain effect on the treatment of malignant tumors, especially for patients with advanced lung cancer, which can relieve symptoms and prolong survival time. For some patients, tumors can still shrink or even fade. Experimental studies have shown that Pingxiao Tablets inhibits Ehrlich ascites carcinoma and sarcoma S180 in mice. In order to further explore its principle of action, we used the urethane-induced mouse lung adenoma as a model to observe the ultrastructure of tumor cells in the drug-treated and non-drug groups. The experimental animals were Kunming mice, 6 weeks old, weighing 18-22 g and divided into 4 groups. (1) Normal group: Twelve rats were injected intraperitoneally with normal saline. (2) Control group: 12 rats were intraperitoneally injected with 5% urethane solution at a dose of 1.0 mg/g body weight. (3) Pingxiao Tablets: 13 rats, peritoneal injection