论文部分内容阅读
目的：了解口服雷尼替丁在小儿消化性溃疡治疗中的耐受性。方法：对１８例经胃镜检查确诊为消化性溃疡的患儿用雷尼替丁口服治疗，监测疗程第１天、第１周及第４周患儿的胃ｐＨ值动态变化。有４例患儿未完成第１周复查，５例患儿未完成第４周复查。结果：治疗后患儿胃ｐＨ值显著提高，疗程第１周、第４周胃ｐＨ平均值和平均中位值、胃ｐＨ＞３和＞４时间百分比均比第１天降低，药物起效时间延长，药效维持时间缩短，差异有显著意义（Ｐ＜００５）。而疗程第４周胃ｐＨ平均值、胃ｐＨ＞３和＞４时间百分比均比第１周降低，药效维持时间更为缩短，差异有显著性意义（Ｐ＜００５）。结论：口服雷尼替丁治疗小儿消化性溃疡时，在疗程第１周即产生耐受性，至第４周其耐受性更为加重。
OBJECTIVE: To understand the tolerability of oral ranitidine in the treatment of pediatric peptic ulcer disease. Methods: 18 children with peptic ulcer diagnosed by gastroscopy were treated with ranitidine orally, and the changes of gastric pH value on the first, the first and the fourth week of the course of treatment were monitored. 4 cases did not complete the first week of review, 5 cases did not complete the first 4 weeks of review. Results: After treatment, the gastric pH value of children was significantly increased. The average and mean gastric pH value, gastric pH> 3 and> 4 time points in the first and fourth week of treatment were lower than those in the first day after treatment. The onset time Prolonged, shorter maintenance efficacy, the difference was significant (P <0 05). The average gastric pH, gastric pH> 3 and> 4 time percentage in the 4th week of treatment were all lower than those in the 1st week, and the duration of the drug maintenance was shortened. The difference was significant (P <005). Conclusions: When oral ranitidine is used to treat pediatric peptic ulcer, it is tolerated in the first week of the course of treatment and is more tolerated in the fourth week.