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目的检测Runx3蛋白在宫颈癌组织中的表达,探讨Runx3蛋白与宫颈癌发生、发展、临床病理特征及患者预后之间的关系。方法采用免疫组织化学SP法,检测78例宫颈癌组织、21例宫颈上皮内瘤变组织及20例因良性病变切除子宫的正常宫颈组织中Runx3蛋白的表达。结果 Runx3蛋白在宫颈癌、宫颈上皮内瘤变及正常宫颈癌组织中的中阳性表达率分别为35.7%、68.6%及93.6%,且差异均有统计学意义(P<0.05);Runx3蛋白阳性表达与宫颈癌组织病理分级、浸润深度、淋巴结转移有关,而与患者的年龄、大小及临床分期无关;Runx3蛋白表达阳性者的生存率高于表达阴性者的生存率(P<0.05)。结论 Runx3蛋白的低表达与宫颈癌的发生发展密切相关,可作为评估宫颈癌患者预后的一项重要指标。
Objective To detect the expression of Runx3 protein in cervical cancer and to explore the relationship between Runx3 protein and occurrence, development, clinicopathological characteristics and prognosis of cervical cancer. Methods Immunohistochemical SP method was used to detect the expression of Runx3 protein in 78 cases of cervical cancer, 21 cases of cervical intraepithelial neoplasia and 20 cases of normal cervix. Results The positive rates of Runx3 protein in cervical cancer, cervical intraepithelial neoplasia and normal cervical cancer were 35.7%, 68.6% and 93.6%, respectively, with statistical significance (P <0.05). Runx3 protein was positive The expression was related to the histological grade, depth of invasion and lymph node metastasis of cervical cancer, but not to the age, size and clinical stage of patients with cervical cancer. The survival rate of Runx3 positive patients was higher than that of negative ones (P <0.05). Conclusion The low expression of Runx3 protein is closely related to the occurrence and development of cervical cancer, which can be used as an important index to evaluate the prognosis of patients with cervical cancer.