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虽然已知血管紧张素 II、ACTH 及 K~+都能刺激醛固酮释放,但对于醛固酮的释放仍然有一些现象不能以这些刺激物的作用来解释。已有报告指出,垂体中存在着一些非 ACTH 的因子能刺激醛固酮的释放。β-趋脂素(β-lipotropin,β-LPH)和 ACTH 都是由垂体细胞中的一种前体物质分裂后形成的。β-LPH又可以进一步分解成β-内啡肽。这些微妙的关系引起了人们对它们的重视。最近,美国俄亥俄州医学院的Matsuoka 等报告指出,β-LPH 也是一种刺激醛固酮释放的促激素。他们把大鼠的肾上腺皮质放在含有胶元酶的基质中孵育并结合离心的方法,将其分解成球状带细胞和非球状带细胞(束状带、网状带和髓质细胞)。球状带细胞在含有羊或人的垂体β-LPH 的基质中孵育,能释放醛固酮。β-LPH 的浓度在10~(-9)M 时,即可引起醛固酮的明显增加;在3×10~(-8)M 至10~(-7)M 的浓度范围内可引起醛固酮释放的半最大反应(half-maximum increase)。β-LPH 引起醛固酮释放的最大反应比血管紧
Although it is known that both angiotensin II, ACTH, and K ~ + stimulate aldosterone release, there are still some phenomena that can not be explained by the action of these stimuli on aldosterone release. It has been reported that there are some non-ACTH factors in the pituitary that stimulate the release of aldosterone. β-lipotropin (β-LPH) and ACTH are formed by the division of a precursor substance in pituitary cells. β-LPH can be further broken down into β-endorphin. These delicate relationships arouse people’s attention to them. Recently, the United States Ohio School of Medicine Matsuoka and other reports pointed out that β-LPH is also a hormone that stimulates the release of aldosterone. They incubated the rat adrenal cortex with a matrix containing procollagen and centrifuged, breaking it down into globular and non-globular cells (fascicles, reticular bands and medulla). Spheroidal tape cells are incubated in a matrix containing sheep or human pituitary β-LPH, which releases aldosterone. The concentration of β-LPH in 10 ~ (-9) M, can cause a significant increase in aldosterone; in the range of 3 × 10 ~ (-8) M to 10 ~ (-7) M concentration can cause aldosterone release Half-maximum increase. β-LPH caused aldosterone release than the maximum response to tight blood vessels