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硫唑嘌呤(Aza)发生急性过敏反应,包括发热、寒战和肌痛已有报告。作者报告两例类风湿性关节炎患者用 Aza 后招致严重反应,血压显著下降。据知既往仅有一起类似的报道。例1,女性,50岁,患类风湿性关节炎14年,高血压7年。因关节炎加重,金制剂失效,D-青霉胺产生蛋白尿,遂启用 Aza50mg/d,14天后突然全身不适,发热38℃,寒战和相对低血压。未发现感染灶,血和尿培养阴性,白细胞不增多。停用 Aza,静
Acute allergic reactions to azathioprine (Aza), including fever, chills and myalgia, have been reported. The authors report two cases of rheumatoid arthritis patients with Aza lead to severe reactions, blood pressure decreased significantly. It is known that there has been only one similar report in the past. Example 1, female, 50 years old, suffering from rheumatoid arthritis 14 years, 7 years of high blood pressure. Due to increased arthritis, gold preparations failed, D-penicillamine produce proteinuria, then enable Aza50mg / d, 14 days after a sudden general malaise, fever 38 ℃, chills and relative hypotension. No foci were found, blood and urine cultures were negative, and white blood cells did not increase. Disable Aza, static