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目的探讨纳洛酮治疗新生儿肺炎的临床效果。方法选取2013年10月—2014年10月曲沃县人民医院收治的新生儿肺炎患儿108例,随机分为对照组与治疗组,各54例。两组患儿均给予常规治疗,对照组患儿在常规治疗基础上予以地塞米松治疗,治疗组患儿在常规治疗基础上予以纳洛酮治疗。观察两组患儿治疗前后呼吸功能(Pa O2、Pa CO2)、给氧时间、临床疗效及不良反应发生情况。结果治疗前两组患儿Pa O2、Pa CO2比较,差异无统计学意义(P>0.05),治疗后治疗组患儿Pa O2高于对照组,Pa CO2低于对照组,给氧时间短于对照组,总有效率高于对照组,差异有统计学意义(P<0.05);两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论纳洛酮治疗新生儿肺炎的临床效果显著,不良反应小,安全性高。
Objective To investigate the clinical effect of naloxone on neonatal pneumonia. Methods A total of 108 neonates with pneumonia admitted to the Quwo County People’s Hospital from October 2013 to October 2014 were randomly divided into control group and treatment group, 54 cases each. Children in both groups were given conventional treatment. Children in the control group were treated with dexamethasone on the basis of routine treatment. Children in the treatment group were treated with naloxone on the basis of routine treatment. Before and after treatment, the respiratory function (Pa O2, Pa CO2), oxygen administration time, clinical efficacy and incidence of adverse reactions in both groups were observed. Results There was no significant difference in the Pa O2 and Pa CO2 between the two groups before treatment (P> 0.05). After treatment, the Pa O2 in the treatment group was higher than that in the control group, Pa CO2 was lower than that in the control group, and the oxygenation time was shorter The total effective rate of the control group was higher than that of the control group, with significant difference (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Naloxone treatment of neonatal pneumonia clinical effect is significant, adverse reactions, high safety.