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关于固定剂量合并药物治疗的问题已有多年。多数反对者认为:它並不具有较佳之药理反应,反之,应用各种单一药物分别治疗,却更灵活,且其剂量更具有个体化之特点。作者对螺旋内脂(Spironolactone)或氨苯喋啶(triamterene) (一种钾保留剂)与氢氯噻嗪(bydrochlorothiazide)固定剂量合并应用于32例慢性充血性心力衰竭的病人,并同时单独使用呋喃苯胺酸(速尿furosemido)共16周,并采用双盲法评价,虽然两种合并药物组
There have been many years of problems with fixed-dose medications. Most opponents believe that: it does not have a better pharmacological response, on the contrary, the application of a variety of single drug treatment, but more flexible, and its dose is more individualized. The authors applied a fixed dose combination of Spironolactone or triamterene, a potassium retention agent, and bydrochlorothiazide, to 32 patients with chronic congestive heart failure and treated with furosemide alone (Furosemido furosemide) for 16 weeks and evaluated by double-blind method, although the two combined drug groups