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1984～1994年,我院收治药物致急性肾功能衰竭52例,现就其病因分析并讨论如下。 资料分析:本组男30例,女22例;年龄9～83岁,平均50.43±15.6岁;平均病程16.85±4.97天。查BUN47.72±11.83mmol/L,Cr834.54±362.48μmol/L,血Na~+145.43±11.2mmol/L、K~+50.01±1.74mmol/L,CO_2-CP15.32±7.64mmol/L。本组52例中,由庆大霉素所致者共27例;其次为低分子右旋糖酐10例,醋氮酰胺、甘露醇、四环素各3例,口服复方新诺明及静滴病毒唑各2例,口服苍耳煎剂和静注蛇毒各1例。本组行血液透析26例、腹膜透析22例、非透析疗法4例。死亡12例,病死率为19.35％。
From 1984 to 1994, 52 cases of acute renal failure caused by medicine in our hospital were analyzed and discussed as follows. Data Analysis: The group of 30 males and 22 females; aged 9 to 83 years, mean 50.43 ± 15.6 years; average duration of 16.85 ± 4.97 days. BUN47.72 ± 11.83mmol / L, Cr834.54 ± 362.48μmol / L, blood Na ~ + 145.43 ± 11.2mmol / L, K ~ +50.01 ± 1.74mmol / L, CO_2-CP15.32 ± 7.64mmol / L . The group of 52 cases, caused by gentamicin, a total of 27 cases; followed by 10 cases of low molecular weight dextran, acetazolamide, mannitol, tetracycline in 3 cases, oral cotrimoxazole and intravenous ribavirin 2 Cases, oral Xanthium decoction and intravenous snake venom in 1 case. The group of hemodialysis in 26 cases, peritoneal dialysis in 22 cases, non-dialysis therapy in 4 cases. 12 cases died, the case fatality rate was 19.35%.