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目的探讨乳腺癌保乳根治术后同时进行辅助放疗和化疗的可行性。方法乳腺癌保乳根治术患者40例随机分为两组各20例,研究组术后行1周期辅助化疗,在第2周期辅助化疗同时进行辅助放疗;对照组术后先行1周期辅助化疗,再行辅助放疗,然后进行剩余周期的辅助化疗。对比其2、3、4、5周期辅助化疗时的副反应,辅助治疗结束后随访6个月。结果研究组在第3周期的白细胞下降明显,在第4周期研究组的口腔黏膜炎也比较明显,与对照组相比差异有统计学意义(P<0.05);其余的副反应如放疗区皮肤反应、胃肠反应、脱发、关节疼痛、神经毒性和肝功能异常等两组差异无统计学意义。随访6月两组对比血象、肝肾功能、心电图和胸部X线片等差异无统计学意义。结论乳腺癌保乳根治术后同时进行辅助化疗和放疗患者可耐受,安全可行。
Objective To investigate the feasibility of adjuvant radiotherapy and chemotherapy after breast-conserving radical operation. Methods Forty patients with breast conserving radical mastectomy were randomly divided into two groups of 20 cases. The study group received one-period adjuvant chemotherapy after adjuvant chemotherapy and adjuvant radiotherapy at the second cycle. The control group received adjuvant chemotherapy after one cycle, Adjuvant radiotherapy and then the remaining cycles of adjuvant chemotherapy. Compared with 2,3,4,5 cycles of adjuvant chemotherapy side effects, adjuvant therapy after 6 months of follow-up. Results The leukopenia of the study group was significant at the third cycle, and the oral mucositis was also significant at the fourth cycle in the study group, with statistical significance compared with the control group (P <0.05). The remaining side effects such as skin radiotherapy area Response, gastrointestinal reactions, hair loss, joint pain, neurotoxicity and liver dysfunction and other two groups showed no significant difference. Follow-up in June two groups compared blood, liver and kidney function, ECG and chest X-ray showed no significant difference. Conclusion Breast-conserving breast-conserving therapy is safe and feasible for both patients with adjuvant chemotherapy and radiotherapy.