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目的：为探讨ＴＮＦ诱导白血病细胞程序性死亡的发生机制。方法：应用体外细胞毒性试验，电镜及流式细胞仪进行检测和观察。结果：ＴＮＦ可诱导白血病细胞程序性死亡和杀伤白血病细胞，随着其浓度增加，凋亡细胞数也增加。结论：ＴＮＦ介导白血病细胞程序性死亡在白血病患者的治疗中有重要价值。
Objective: To explore the mechanism of TNF-induced apoptosis in leukemia cells. Methods: In vitro cytotoxicity assays, electron microscopy and flow cytometry were used for detection and observation. RESULTS: TNF induced programmed cell death and killing of leukemia cells. As the concentration increased, the number of apoptotic cells increased. Conclusion: TNF-mediated programmed cell death in leukemia cells has important value in the treatment of leukemia patients.