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对４０例小儿先天性心脏病心内直视手术病例血清胆红素作前瞻性研究，术后总胆红素增高９例（２２．５％），直接胆红素增高６例（１５％），室间隔缺损（ＶＳＤ）及房间隔缺损者高胆红素血症发生率分别为２２．６％和２２．２％（Ｐ＞０．０５），２４例单纯ＶＳＤ发生２例，７例ＶＳＤ伴肺动脉高压（ＰＨ）发生５例（Ｐ＜０．０１）．９例均在术后２４小时内出现，７例第二天恢复正常，２例ＶＳＤ＋ＰＨ持续４和１４天。结果提示，高胆红素血症的发生与体外循环时间、术前心功能状态及病变严重程度有关。
Forty cases of pediatric congenital heart disease in open heart surgery cases of serum bilirubin for prospective study, total bilirubin in 9 cases (22.5%), direct bilirubin in 6 cases (15%), , Ventricular septal defect (VSD) and atrial septal defect were 22.6% and 22.2% respectively (P> 0.05), 24 cases of simple VSD occurred in 2 cases and 7 cases of VSD With pulmonary hypertension (PH) occurred in 5 cases (P <0.01). Nine cases occurred within 24 hours after surgery, 7 cases returned to normal the next day, 2 cases of VSD + PH lasted 4 and 14 days. The results suggest that the occurrence of hyperbilirubinemia and cardiopulmonary bypass time, preoperative cardiac function and disease severity.